Ferroptosis in hepatic ischemia?reperfusion injury: Regulatory mechanisms and new methods for therapy (Review)

Ischemia?reperfusion injury (IRI), also called reoxygenation injury, is the outcome of inflammatory processes and oxidative damage through induction stress. In clinical setting, IRI contributes to severe hepatic including liver cell death by apoptosis ferroptosis. Ferroptosis a novel type in that involves small molecules inhibit glutathione biosynthesis or peroxidase 4 (GPX4), which glutathione?dependent antioxidant enzyme, causing mitochondrial damage. Currently, ferroptosis has been systematically described neurological settings, kidney diseases different types cancer, while few studies have analysed presence regulatory mechanism IRI. Exploring exact role played following accordance with existing evidence mechanisms could guide potential therapeutic interventions provide research avenue.